Unknown Male Infertility

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Why MiOXSYS?

  • Highly Accurate: High Specificity 88% and PPV 97% in accordance with the latest edition of the WHO parameters for identification of normal and abnormal semen analysis. Accurate detection for better patient management and treatment goals related to fertility.

  • Easy to use: Less than 1 min hands on time, ensuring the most efficient use of staff time; use with fresh or frozen semen samples.

  • Fast: Results in as quickly as 5 minutes, so you can deliver same day results to your clinicians.

 

The Need

Male Infertility Factor is the primary cause of infertility in 20-30% of the cases. It is estimated that this condition affects 30 million globally.

  • Approximately $244MM in healthcare costs associated with this condition.

  • 25-40% of the male infertility cases are diagnosed as idiopathic and implicated due to oxidative stress.

  • High levels of oxidative stress have been linked to abnormal sperm function, resulting abnormal semen parameters and failed IVF outcomes:

    • Lipid peroxidation which damages the sperm surface causing an abnormal morphology and impaired motility

    • Damage to proteins on cell surface responsible for cell signaling and may affect enzyme function inside the cell

    • Peroxidation of DNA and subsequent unraveling or fragmentation

    • Impaired fertilization by affecting sperm capacitation and acrosome reaction

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The Solution

Identifying idiopathic cases of male infertility requires an accurate, easy to use test that is capable of measuring oxidative stress.

MiOXSYS™s sORP measure is based upon the principle of Oxidation-Reduction Potential, which measures the giving and taking of electrons. Unlike other measures, sORP represents an integrated measure of oxidants and reductants, making it a more clinically meaningful measure.

  • In clinical validation studies MiOXSYS™ sORP provides a superior PPV, which is required of a rule-in test.

  • The MiOXSYS System enables laboratory efficiencies with stat capability, requiring less than 1 minute hands on time, and results in 3 minutes.

REFERENCES

  1. American Pregnancy Association

  2. Tremellen K. Oxidative stress and male infertility – a clinical perspective. Hum Reprod Update. 2008 May-Jun;14(3):243-58.

  3. Agarwal A, et al. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015.

  4. Allied Market Research Report 2012.

  5. Sigman M, Howards SS (1998). Male infertility. In: Walsh PC, Retik AB,Vaughan Jr ED, Wein AJ, editors. Campbell’s Urology (7th ed.) Philadelphia:WB Saunders Company. 1287-1320.

  6. Agarwal A. Diagnostic application of oxidation-reduction potential assay for measurement of oxidative stress in male factor infertility. Reprod Biomed. 2016.

The MiOXSYS System

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